Dr. Yalan Xing
Office: SCIE 4062
Position: Assistant Professor
Area Specialization: Organic Chemistry
Postdoctoral Research Fellow, Harvard University, May 2011 – June 2014
Ph.D., Organic Chemistry, West Virginia University, May 2011
B.S., Applied Chemistry, Beijing University of Chemical Technology, July 2006
Research Interests: Organic Chemistry
My research mission is to develop novel synthetic methodologies to provide unique access to bioactive small molecule agents and ultimately address the increasing needs in biomedical research, particularly cancer research. I am especially interested in invention of next generation synthetic methodologies, which display improved efficiencies and are atom economical. My approach to these challenges is to develop novel transition metal catalysis enabling carbon-carbon and carbon-heteroatom bonds formation from simple alkyne hydration. I plan to use these methods to prepare natural products, pharmaceutical agents and their analogs, and then study their biological activities.
1) Develop efficient metholologies for organic synthesis
2) Synthesize bioactive small molecule agents
3) Study medicinal chemistry SAR
1. B. Catano, J. Lee, C. Kim, D. Farrell, J. L. Petersen, Y. Xing. “Iron(III) catalyzed halo-functionalization of alkynes” Tetrahedron Letters, 2015, 56, 4124
2. X. Lan, N. Wang, W. Zhang, J. Wen, C. Bai, Y. Xing, Y.Li. “Copper/Manganese Cocatalyzed Oxidative Coupling of Vinylarenes with Ketones” Organic Letters, 2015, 17, 4460.
3. X. Yang, M. Wu, S. Sun, C. Huang, H. Guo, J. Wang, J. Lee, Y. Xing.* “Synthesis of tricyclic quinazolinones via intramolecular cyclization of 3-(2-aminoalkyl)-2-(phenylamino)quinazolin-4(3H)-ones” Molecular Diversity, 2015, DOI 10.1007/s11030-015-9636-9
4. W. Shi, S. Sun, M. Wu, B. Catano, W. Li, J. Wang, H. Guo, Y. Xing. “Highly regioselective synthesis of cis-b -enaminones by 1,4-addition of propioaldehydes” Tetrahedron Letters, 2015, 56, 468.
1. P. J. Converse, Y. Xing, K. H. Kim, Y. Kishi. “Accelerated detection of mycolactone production and response to antibiotic treatment in mouse model of Mycobacterium ulcerans disease” PLoS Neglected Tropical Disease, 2014, 8, e2618.
2. Y. Xing, S. M. Hande, Y. Kishi. “Photochemistry of Mycolactone A/B, the Causative Toxin of Buruli Ulcer” Journal of the American Chemical Society, 2012, 134, 19234.
3. Y. Xing, N. Wang. “Organocatalytic and Metal-Mediated Asymmetric [3+2] Cycloaddition Reactions” Coordination Chemistry Reviews, 2012, 256, 938.
4. M. Shan, Y. Xing, G. A. O’Doherty. “De Novo Asymmetric Synthesis of an α-6-Deoxyaltropyranoside as Well as its 2-/3-Deoxy and 2,3-Dideoxy Congeners” Journal of Organic Chemistry, 2009, 74, 5961.
5. Y. Xing, G. A. O’Doherty. “De Novo Asymmetric Synthesis of Cladospolide B-D: Structural Reassignment of Cladospolide D via the Synthesis of its Enantiomer” Organic Letters, 2009, 11, 1107.
6. T. J. Baiga, H. Guo, Y. Xing, G. A. O’Doherty, A. Dillin, M. B. Austin, J. P. Noel, J. J. La Clair. “Metabolite Induction of Caenorhabditis Elegans Dauer Larvae Arises via Transport in the Pharynx” ACS Chemical Biology, 2008, 3, 293.