Office: 4062 SCE
Postdoctoral Research Fellow, Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA
Research focused on the synthesis of ergot alkaloid based P450 inhibitors and their protein-binding studies (August 2011-2014)
Postdoctoral Research Fellow, Department of Chemistry, Northwestern University, Evanston, IL
Research based on the synthesis and characterization of porphyrin- and dipyridyl-based Metal-Organic Frameworks (MOFs) and catechol-based Porous Organic Polymers (POPs) (August 2010-August 2011)
Ph.D; Organic Chemistry, Texas Tech University, Lubbock, TX
Thesis Title:“Chiral and achiral N-phosphonyl imine chemistry and GAP synthesis of amino derivatives” (December 2010)
M.S. Department of Chemistry, University of Delhi, Delhi, India
University of California, Irvine: May 2013-Dec 2014 (Worked as Assistant Research Specialist III; as well as Postdoctoral fellow (2011-2013): Advisor: Prof. A. Richard Chamberlin )
Northwestern University: August 2010-August 2011 (worked as a postdoctoral researcher)
Texas Tech University: August 2005 - August 2010 (worked as a Teaching and Research Assistant)
Dr. Reddy’s Laboratories: May 2003- Jan 2004 (worked as a Chemist)
My current research is focused on the synthesis of biologically active molecules of pharmaceutical importance and their chemical biology aspects. The proposed research is at the interface of synthetic organic chemistry, chemical biology, pharmaceutical sciences and drug discovery. By interfacing different aspects of asymmetric catalysis, SAR based drug design, molecular modeling and chemical biology, the development of solution strategies are intended against various challenges in the fields of drug discovery, complex reaction systems and protein chemistry. My research group will also focus on the synthesis of highly porous metal-organic frameworks and their use as catalysts.
The main avenues that my research group will be focusing on are as follows:
1) Design and synthesis of peptide based simpler analogs for cytochrome P450 inhibition;
2) Fragment based ligand/library synthesis
3) New method development for the synthesis of novel chiral phosphoramides
4) Synthesis of highly porous metal-organic frameworks
Structure-based inhibitor design for evaluation of a CYP3A4 pharmacophore model, Parminder Kaur, A. Richard Chamberlin, Thomas L. Poulos, and Irina F. Sevrioukova J. Med, Chem. (ASAP article 2016) DOI: 10.1021/acs.jmedchem.5b01146.
Modeling linear PKS intermediates through atom replacement, Gaurav Shakya, David Lee, Matthew Jaremko, James LaClair, Heriberto Rivera, Daniel Fox, Parminder Kaur, Emily Gwozdziowski, Fiona Wong, Sheryl Tsai and Michael Burkart J. Am. Chem. Soc., 2014, 136 (48), 16792–16799.
Porous organic polymers (POPs) in catalysis - Opportunities and Challenges. Parminder Kaur, Joseph T. Hupp and SonBinh T. Nguyen, ACS Catalysis 2011, 1(7), 819. (Top 10 Most Read Articles in Q3 2011 from ACS Catalysis).
The GAP chemistry for Chiral N-Phosphonyl imine-based Strecker reaction, Parminder Kaur, Walter Wever, Suresh Pindi, Raizada Milles, Peng Gu, Min Shi and Guigen Li, Green Chemistry 2011, 13, 1288.
A new rapid multicomponent domino reaction for the formation of functionalized benzo[h]pyrazolo [3,4-b]quinolines, Bo Jiang, Ge Zhang, Ning Ma, Feng Shi, Shu-Jiang Tu, Parminder Kaur and Guigen Li, Org. Biomol. Chem. 2011, 9, 3834.
Asymmetric hydrophosphylation of chiral N-phosphonyl imines provides an efficient approach to chiral a-amino phosphates. Parminder Kaur, Walter Wever, Trideep Rajale and Guigen Li. Chemical Biology and Drug Design2010, 76(4), 314.
Asymmetric catalytic Strecker reaction of N-phosphonylimines with Et2AlCN using amino alcohols and BINOLs as catalysts. Parminder Kaur, Suresh Pindi, Walter Wever, Trideep Rajale and Guigen Li Chem. Commun. 2010, 46, 4330.
Asymmetric catalytic N-phosphonylimine chemistry: The use of primary free amino acids to control asymmetric catalytic Strecker reaction. Parminder Kaur, Suresh Pindi, Walter Wever, Trideep Rajale and Guigen Li J. Org. Chem. 2010, 75, 5144.
Chiral N-phosphonylimine chemistry: A convenient asymmetric method for the synthesis of N-phosphonyl substituted chiral propargylamines. Parminder Kaur, Gaurav Shakya, Sun Hao, Yi Pan and Guigen Li Org. Biomol. Chem. 2010,8, 1091.
Four-component domino reaction providing an easy access to multifunctionalized tricyclo [126.96.36.199] dodecane derivatives. Bo Jiang, Chao Li, Feng Shi, Shu-Jiang Tu, Parminder Kaur, Walter Wever and Guigen Li J. Org. Chem.2010, 75, 2962.
N-phosphinyl imine chemistry (I): Design and synthesis of novel N-phosphinyl imines and their application to asymmetric aza-henry reaction. Suresh Pindi, Parminder Kaur, Gaurav Shakya and Guigen Li Chemical Biology and Drug Design 2010, 77(1), 20.
Chiral N-phosphonylimine chemistry: A convenient asymmetric method for the synthesis of N-phosphonyl ß-amino Weinreb amides. Parminder Kaur, Thao Nguyen and Guigen Li Eur. J. Org. Chem. 2009, 912.
Four-component domino reaction leading to multifunctionalized quinazolines. Bo Jiang, Shu-Jiang Tu, Parminder Kaur, Walter Wever and Guigen Li J. Am. Chem. Soc. 2009, 11660.
Chiral N-phosphonylimine chemistry: Asymmetric additions of malonate-derived enolates to chiral N-phosphonyl imines for the synthesis of ?-aminomalonates. Zhong-Xiu Chen, Teng Ai, Parminder Kaur and Guigen LiTetrahedron Lett. 2009, 50, 1079.
Chiral N-phosphonyl imine chemistry: Asymmetric aza-Henry reaction. Adiseshu Kattuboina, Parminder kaur, Teng Ai, Guigen Li. Chemical Biology and Drug Design 2008, 71(3), 216.
Chiral N-phosphonylimine chemistry: Asymmetric 1,2-additions of allylmagnesium bromides. Adiseshu Kattuboina,Parminder Kaur, Thao Nguyen and Guigen Li Tetrahedron Lett. 2008, 49, 3722.
Novel approach to multifunctionalized homoallylic alcohols via regioselective ring- opening of aryl oxiranes with 3-Iodo Allenoates. Adiseshu Kattuboina, Parminder Kaur, Cody Timmons and Guigen Li Org. Lett. 2006, 8, 2771.